Journal Cover Articles

Selected Publications

  • [34] A transgene-free, human peri-gastrulation embryo model with trilaminar embryonic disc-, amnion- and yolk sac-like structures
    Shiyu Sun, Yi Zheng, Norio Kobayashi, Yung Su Kim, Xuefeng Xue, Yue Liu, Yanhong Xu, Jinglei Zhai, Hongmei Wang, and Jianping Fu
    bioRxiv, 2024.
    DOI: 10.1101/2024.08.05.606556.
    | PDF | Supplemental Materials | PubMed
  • [33] Criteria for standardization of stem-cell-based embryo models
    Alfonso Martinez Arias, Nicolas Rivron, Naomi Moris, Patrick Tam, Cantas Alev, Jianping Fu, Anna-Katerina Hadjantonakis, Jacob H. Hanna, Gabriella Minchiotti, Olivier Pourquie, Guojun Sheng, Liliana Solnica Krezel, Jesse Veenvliet, and Aryeh Warmflash
    Nature Cell Biology, in press, 2024.
    DOI: 10.1038/s41556-024-01492-x.
    | PDF | PubMed
  • [32] A comprehensive human embryo reference tool using single-cell RNA-sequencing data
    Cheng Zhao, Alvaro Plaza Reyes, John Paul Schell, Jere Weltner, Nicolás M. Ortega, Yi Zheng, Åsa K. Björklund, Joonas Sokka, Ras Torokovic, Brian Cox, Janet Rossant, Jianping Fu, Sophie Petropoulos, and Fredrik Lanner
    Nature Methods, in press, 2024.
    | PDF | PubMed
  • [31] Bioengineering embryo models
    Xufeng Xue, Yue Liu, and Jianping Fu
    Nature Reviews Bioengineering, in press, 2024.
    DOI: 10.1038/s44222-024-00241-x.
    | PDF | PubMed
  • [30] Towards developing human organs via embryo models and chimeras
    Jun Wu and Jianping Fu
    Cell, vol. 187, pp. 3194-3219, 2024.
    DOI: 10.1016/j.cell.2024.05.027.
    | PDF | PubMed
  • [29] A human pluripotent stem cell-based somitogenesis model using microfluidics
    Yue Liu, Yung Su Kim, Xufeng Xue, Yuchuan Miao, Norio Kobayashi, Shiyu Sun, Robin Zhexuan Yan, Qiong Yang, Olivier Pourquié, and Jianping Fu
    Cell Stem Cell, vol. 31, pp. 1113-1126, 2024.
    DOI: 10.1101/2023.10.29.564399.
    | PDF | Supplemental Materials | PubMed
  • [28] A patterned human neural tube model using microfluidic gradients
    Xufeng Xue, Yung Su Kim, Alfredo-Isaac Ponce-Arias, Richard O'laughlin, Robin Zhexuan Yan, Norio Kobayashi, Rami Yair Tshuva, Yu-Hwai Tsai, Shiyu Sun, Yi Zheng, Yue Liu, Frederick C.K. Wong, Azim Surani, Jason R. Spence, Hongjun Song, Guo-Li Ming, Orly Reiner, and Jianping Fu
    Nature, vol. 628, pp. 391-399, 2024.
    DOI: 10.1038/s41586-024-07204-7.
    | PDF | Supplemental Materials | PubMed
  • [27] Regulation of long-range BMP gradients and embryonic polarity by propagation of local calcium-firing activity
    Hyung Chul Lee, Nidia M. M. Oliveira, Cato Hastings, Peter Baillie-Benson, Adam A. Moverley, Hui-Chun Lu, Yi Zheng, Elise L. Wilby, Timothy T. Weil, Karen M. Page, Jianping Fu, Naomi Moris, and Claudio D. Stern
    Nature Communications, vol. 15, 1463, 2024.
    DOI: 10.1038/s41467-024-45772-4.
    | PDF | Supplemental Materials | PubMed
  • [26] Derivation of human primordial germ cell-like cells in an embryonic-like culture
    Sajedeh Nasr Esfahani, Yi Zheng, Auriana Arabpour, Agnes M. Resto Irizarry, Norio Kobayashi, Xufeng Xue, Yue Shao, Cheng Zhao, Nicole L. Agranonik, Megan Sparrow, Timothy J. Hunt, Jared Faith, Mary Jasmine Lara, Qiu Ya Wu, Sherman Silber, Sophie Petropoulos, Ran Yang, Kenneth R. Chien, Amander T. Clark, and Jianping Fu
    Nature Communications, vol. 15, 167, 2024.
    DOI: 10.1038/s41467-023-43871-2.
    | PDF | Supplemental Materials | PubMed

    Featured in Nature Communications Editors’ Highlights
  • [25] Morphogenesis beyond in vivo
    Yue Liu, Xufeng Xue, Shiyu Sun, Norio Kobayashi, Yung Su Kim, and Jianping Fu
    Nature Reviews Physics, vol. 6, pp. 28-44, 2024.
    DOI: 10.1038/s42254-023-00669-x.
    | PDF | PubMed
  • [24] Changing the public perception of human embryology
    Nicolas C. Rivron, Alfonso Martinez-Arias, Karen Sermon, Christine Mummery, Hans Schöler, James Wells, Jenny Nichols, Anna-Katerina Hadjantonakis, Madeline A. Lancaster, Jianping Fu, Janet Rossant, and Kazuto Kato
    Nature Cell Biology, vol. 25, pp. 1717-1719, 2023.
    DOI: 10.1038/s41556-023-01289-4.
    | PDF | PubMed
  • [23] Why researchers should use human embryo models with caution
    Janet Rossant and Jianping Fu
    Nature, vol. 622, pp. 22-24, 2023.
    DOI: 10.1038/d41586-023-03062-x.
    | PDF | PubMed
  • [22] Mechanically enhanced biogenesis of gut spheroids with instability-driven morphomechanics
    Feng Lin, Xia Li, Shiyu Sun, Zhongyi Li, Jianbo Bai, Lin Song, Bo Li, Jianping Fu, and Yue Shao
    Nature Communications, vol. 14, 6016, 2023.
    DOI: 10.1038/s41467-023-41760-2.
    | PDF | Supplemental Materials | PubMed
  • [21] Dissecting peri-implantation development using cultured human embryos and embryo-like assembloids
    Zongyong Ai, Baohua Niu, Yu Yin, Lifeng Xiang, Gaohui Shi, Kui Duan, Sile Wang, Yingjie Hu, Chi Zhang, Chengting Zhang, Lujuan Rong, Ruize Kong, Tingwei Chen, Yixin Guo, Wanlu Liu, Nan Li, Shumei Zhao, Xiaoqing Zhu, Xuancheng Mai, Yonggang Li, Ze Wu, Yi Zheng, Jianping Fu, Weizhi Ji, and Tianqing Li
    Cell Research, vol. 33, pp. 661-678, 2023.
    DOI: 10.1038/s41422-023-00846-8.
    | PDF | Supplemental Materials | PubMed

    Commentary by Janet Rossant, Cell Research, vol. 33, pp. 1-2, 2023. [PDF]
  • [20] Single-cell analysis of embryoids reveals lineage diversification roadmaps of early human development
    Yi Zheng, Robin Zhexuan Yan, Shiyu Sun, Mutsumi Kobayashi, Lifeng Xiang, Ran Yang, Alexander Goedel, Yu Kang, Xuefeng Xue, Sajedeh Nasr Esfahani, Yue Liu, Agnes M. Resto Irizarry, Weisheng Wu, Yunxiu Li, Weizhi Ji, Yuyu Niu, Kenneth R. Chien, Tianqing Li, Toshihiro Shioda, and Jianping Fu
    Cell Stem Cell, vol. 29, pp. 1402-1419, 2022.
    DOI: 10.1016/j.stem.2022.08.009.
    | PDF | Supplemental Materials | PubMed
  • [19] Engineering multiscale structural orders for high-fidelity embryoids and organoids
    Yue Shao, and Jianping Fu
    Cell Stem Cell, vol. 29, pp. 722-743, 2022.
    DOI: 10.1016/j.stem.2022.04.003.
    | PDF | PubMed
  • [18] Amnion signals are essential for mesoderm formation in primates
    Ran Yang, Alexander Goedel, Yu Kang, Chengyang Si, Chu Chu, Yi Zheng, Zhenzhen Chen, Peter J. Gruber, Yao Xiao, Chikai Zhou, Chuen-Yan Leung, Yongchang Chen, Jianping Fu, Weizhi Ji, Fredrik Lanner, Yuyu Niu, and Kenneth Chien
    Nature Communications, vol. 12, 5126, 2021.
    DOI: 10.1101/2020.05.28.118703.
    | PDF | Supplemental Materials | PubMed
  • [17] Force-FAK signaling coupling at individual focal adhesions coordinates mechanosensing and microtissue repair
    Dennis W. Zhou, Marc A. Fernández-Yagüe, Elijah N. Holland, Andrés F. García, Nicolas S. Castro, Eric B. O’Neill, Jeroen E.G. Eyckmans, Christopher S. Chen, Jianping Fu, David D. Schlaepfer, and Andrés J. García
    Nature Communications, vol. 12, 2359, 2021.
    DOI: 10.1038/s41467-021-22602-5.
    | PDF | Supplemental Materials | PubMed
  • [16] Spatially resolved cell polarity proteomics of a human epiblast model
    Sicong Wang, Chien-Wei Lin, Chari L. Cortez, Amber E. Carleton, Craig Johnson, Linnea E. Taniguchi, Ryan F. Townshend, Venkatesha Basrur, Alexey I. Nesvizhskii, Amy W. Hudson, Blake R. Hill, Peng Zou, Jianping Fu, Deborah L. Gumucio, Mara C. Duncan, and Kenichiro Taniguchi
    Science Advances, vol. 7, eabd8407, 2021.
    DOI: 10.1126/sciadv.abd8407.
    | PDF | Supplemental Materials | PubMed
  • [15] First complete model of the human embryo
    Yi Zheng, and Jianping Fu
    Nature, vol. 591, pp. 531-532, 2021.
    DOI: 10.1038/d41586-021-00581-3.
    | PDF | PubMed
  • [14] Stem-cell-based embryo models for fundamental research and translation
    Jianping Fu, Aryeh Warmflash, and Lutolf P. Matthias
    Nature Materials, vol. 20, pp. 132-144, 2021.
    DOI: 10.1038/s41563-020-00829-9. PMCID: PMC7855549.
    | PDF | PubMed
  • [13] Mechanical tension promotes formation of gastrulation-like nodes and patterns mesoderm specification in human embryonic stem cells
    Jonathon M. Muncie, Nadia M.E. Ayad, Johnathon N. Lakins, Xufeng Xue, Jianping Fu, and Valerie M. Weaver
    Developmental Cell, vol. 55, pp. 679-694, 2020.
    DOI: 10.1101/2020.02.10.943076. PMCID: PubMed - in process.
    | PDF | Supplemental Materials | PubMed
  • [12] Dorsal-ventral patterned neural cyst from human pluripotent stem cells in a neurogenic niche
    Yuanyuan Zheng, Xufeng Xue, Agnes M. Resto Irizarry, Zida Li, Yue Shao, Yi Zheng, Gang Zhao, and Jianping Fu
    Science Advances, vol. 5, eaax5933, 2019.
    DOI: 10.1126/sciadv.aax5933. PMCID: PubMed - in process.
    | PDF | Supplemental Materials | PubMed
  • [11] Controlled modeling of human epiblast and amnion development using stem cells
    Yi Zheng, Xufeng Xue, Yue Shao, Sicong Wang, Sajedeh Nasr Esfahani, Zida Li, Jonathon M. Muncie, Johnathon N. Lakins, Valerie M. Weaver, Deborah L. Gumucio, and Jianping Fu
    Nature, vol. 573, pp. 421-425, 2019.
    DOI: 10.1038/s41586-019-1535-2. PMCID: PubMed - in process.
    | PDF | Supplemental Materials | PubMed

    Commentary by Amander T. Clark, Nature, vol. 573, pp. 350-351, 2019. [PDF]
    Highlighted by Nature News, "Embryo-like structures created from human stem cells". (link)
    Highlighted by Nature Podcast, "Modelling early embryos". (link)
    Highlighted by National Public Radio (NPR) News, "Scientists create a device that can mass-produce human embryoids". (link)
    Highlighted by BBC News, "Embryoids from stem cells". (link)
    Highlighted by MIT Technology Review, "Meet the 'artificial embryos' being called uncanny and spectacular". (link)
    Highlighted by Chemical & Engineering News (C&EN), "Microfluidic device brews human embryo-like structures". (link)
  • [10] Debate ethics of embryo models from stem cells
    Nicolas Rivron, Martin Pera, Janet Rossant, Alfonso Martinez Arias, Magdalena Zernicka-Goetz, Jianping Fu, Suzanne van den Brink, Annelien Bredenoord, Wybo Dondorp, Guido de Wert, Insoo Hyun, Megan Munsie, and Rosario Isasi
    Nature, vol. 564, pp. 183-185, 2018.
    DOI: 10.1038/d41586-018-07663-9. PMCID: PubMed - in process.
    | PDF | PubMed
  • [9] Mechanics-guided embryonic patterning of neuroectoderm tissue from human pluripotent stem cells
    Xufeng Xue, Yubing Sun, Agnes M. Resto-Irizarry, Ye Yuan, Koh Meng Aw Yong, Yi Zheng, Shinuo Weng, Yue Shao, Yimin Chai, Lorenz Studer, and Jianping Fu
    Nature Materials, vol. 17, pp. 633-641, 2018.
    DOI: 10.1038/s41563-018-0082-9.
    | PDF | Supplemental Materials | PubMed

    Recommended in F1000Prime by David Schaffer and Rocio Sampayo. [PDF]
    Commentary by Mukul Tewary and Peter W. Zandstra, Nature Materials, vol. 17, pp. 571-572, 2017. [PDF]
  • [8] A pluripotent stem cell-based model for post-implantation human amniotic sac development
    Yue Shao, Kenichiro Taniguchi, Ryan F. Townshend, Toshio Miki, Deborah L. Gumucio, and Jianping Fu
    Nature Communications, vol. 8, 208, 2017.
    DOI: 10.1038/s41467-017-00236-w. PMCID: PMC5547056.
    | PDF | Supplemental Materials | PubMed

    Recommended in F1000Prime by Magdalena Zernicka-Goetz and Marta Shahbazi. [PDF]
    Highlighted by MIT Technology Review, "Artificial human embryos are coming, and no one knows how to handle them". (link)
  • [7] Self-organized amniogenesis by human pluripotent stem cells in a biomimetic implantation-like niche
    Yue Shao, Kenichiro Taniguchi, Katherine Gurdziel, Ryan F. Townshend, Xufeng Xue, Koh Meng Aw Yong, Jianming Sang, Jason R. Spence, Deborah L. Gumucio, and Jianping Fu
    Nature Materials, vol. 16, pp. 419-425, 2017.
    DOI: 10.1038/nmat4829. PMCID: PMC5374007.
    | PDF | Supplemental Materials | PubMed

    Commentary by Martin Pera, Nature Materials, vol. 16, pp. 394-395, 2017. [PDF]
  • [6] Mechanosensitive subcellular rheostasis drives emergent single-cell mechanical homeostasis
    Shinuo Weng, Yue Shao, Weiqiang Chen, and Jianping Fu
    Nature Materials, vol. 15, pp. 961-967, 2016.
    DOI: 10.1038/nmat4654. PMCID: PMC4996707.
    | PDF | Supplemental Materials | PubMed
  • [5] Hippo/YAP-mediated rigidity-dependent motor neuron differentiation of human pluripotent stem cells
    Yubing Sun, Koh Meng Aw Yong, Luis G. Villa-Diaz, Xiaoli Zhang, Weiqiang Chen, Renee Philson, Shinuo Weng, Haoxing Xu, Paul H. Krebsbach, and Jianping Fu
    Nature Materials, vol. 13, pp. 599-604, 2014.
    DOI: 10.1038/nmat3945. PMCID: PMC4051885.
    | PDF | Supplemental Materials | PubMed

    Commentary by Emily Rhodes Lowry & Christopher E. Henderson, Nature Materials, vol. 13, pp. 543-544, 2014. [PDF]
    Commentary by Ning Wang, Cell Stem Cell, vol. 14, pp. 701-703, 2014. [PDF]
  • [4] Adhesive signature-based, label-free isolation of human pluripotent stem cells
    Ankur Singh, Shalu Suri, Ted T. Lee, Jamie M. Chilton, Marissa T. Cooke, Weiqiang Chen, Jianping Fu, Steven L. Stice, Hang Lu, Todd C. McDevitt, and Andrés J. García
    Nature Methods, vol. 10, pp. 438-444, 2013.
    DOI: 10.1038/nmeth.2437. PMCID: PMC3641175.
    | PDF | Supplemental Materials | PubMed

    Commentary by Oscar J. Abilez & Joseph C. Wu, Nature Materials, vol. 12, pp. 474-476, 2013; web link.
  • [3] Mechanical regulation of cell function with geometrically modulated elastomeric substrates
    Jianping Fu, Yang-Kao Wang, Michael T. Yang, Ravi A. Desai, Xiang Yu, Zhijun Liu, and Christopher S. Chen
    Nature Methods, vol. 7, pp. 733-736, 2010.
    DOI: 10.1038/nmeth.1487.  PMCID: PMC3069358.
    | PDF | Supplemental Materials | PubMed

    Commentary by Amnon Buxboim & Dennis Discher, Nature Methods, vol. 7, pp. 695-697, 2010. [PDF]
  • [2] A patterned anisotropic nanofluidic sieving structure for continuous-flow separation of DNA and protein
    Jianping Fu, Reto B. Schoch, Anna L. Stevens, Steven R. Tannenbaum, and Jongyoon Han
    Nature Nanotechnology, vol. 2, pp. 121-128, 2007.
    DOI: 10.1038/nnano.2006.206.  PMCID: PMC2621439.
    | PDF | Supplemental Materials | PubMed

    Commentary by Robert Austin, Nature Nanotechnology, vol. 2, pp. 121-128, 2007. [PDF]
  • [1] Molecular sieving in periodic free-energy landscapes created by patterned nanofilter arrays
    Jianping Fu, Juhwan Yoo, and Jongyoon Han
    Physical Review Letters, vol. 97, 018103, 2006.
    DOI: 10.1103/PhysRevLett.97.018103.  PMCID: PMC1752241.
    | PDF | PubMed

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